MCO 3900.18 — Human Research Protection Program (hrpp)

MCO 3900.18 governs the protection of human subjects in research conducted by, within, or for the U.S. Marine Corps.

Search MCO 3900.18

  • Publication number: MCO 3900.18
  • Title: HUMAN RESEARCH PROTECTION PROGRAM (HRPP)
  • Date: 21 Jan 2011
  • Proponent: 03000 Operations & Readiness
  • Status: New

View MCO 3900.18 on armypubs.army.mil


MCO 3900.18 addresses training, assurance, IRB review, international and classified research, public release, compensation, vulnerable subjects, and misconduct. It requires ethics training, appropriate review and approval, additional safeguards, and reporting of non-compliance and misconduct.

Applies to: This Order is applicable to the Marine Corps Total Force.

Topics covered

  • Human subjects research
  • Research ethics training
  • Institutional assurance
  • IRB review
  • Classified research
  • Vulnerable research subjects
  • Research compensation
  • Research misconduct

Questions and answers

What must be in place before human subjects research begins?

Human subjects research shall not be initiated until the institution holds a valid assurance for the protection of human research subjects, the research protocol has been reviewed by an authorized IRB, and approval granted by an appropriate research approval authority. (paragraph 1)

Who determines whether research involving human participants requires IRB review?

The determination whether or not a research activity requires review by an IRB will be made by an authorized IRB chair/vice chair or an individual duly authorized and trained to make such determinations. (paragraph 2)

What happens when human subjects protection regulations conflict?

In all cases, the regulation, instruction, or policy providing the greatest protection for the human subject shall prevail. (paragraph 3)

What approval is required for classified research with human subjects?

Classified research with human subjects is held to the same ethical principles and human subject protections as unclassified research and must receive prior approval from the Secretary of Defense (SECDEF). (paragraph 5)

Is research involving captured or detained personnel allowed?

Research involving any person captured, detained, held, or otherwise under the control of DOD personnel (military, government civilian, or contractor) is prohibited.

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