AFRLI61-103V2 — Afrl Test Activity Involving Human Participants

AFRLI61-103V2 governs safeguards, reviews, and approvals for AFRL test activities involving human participants or human subjects.

Search AFRLI61-103V2

  • Publication number: AFRLI61-103V2
  • Title: AFRL TEST ACTIVITY INVOLVING HUMAN PARTICIPANTS
  • Date: 2026-05-07

View AFRLI61-103V2 on armypubs.army.mil


It covers purpose and scope, assigned roles, and the test process for research, evaluation, and demonstration activities involving humans. It requires safety planning, applicable reviews, informed consent, participant protections, and compliant handling of participant information.

Topics covered

  • Human participant and human subject safety
  • Test activity reviews and approvals
  • Human Subject Worksheet
  • Institutional Review Board determinations
  • Test plan safety requirements
  • Informed consent
  • Participant data privacy

Questions and answers

Who can make an official human subjects research determination?

Only approved staff of the AFRL IRB is authorized to make official human subjects research determinations. (paragraph 2)

When must test plans be coordinated before testing with human participants?

IAW DAFI 91-202_AFMCSUP_AFRLSUP all test plans must be coordinated with the appropriate qualified professional at the AFRL Site/Detachment Safety Office prior to conducting any tests with human participants and the AFRL IRB if involving human subjects. (paragraph 3)

How should testing involving human participants be conducted?

The test should be conducted in such a way as to avoid any mental or physical harm or unnecessary discomfort to participants. (paragraph 3)

When can a test involving human participants be terminated?

During the course of the test, the PM, scientist, or engineer in charge must be prepared to terminate the test at any stage, if he or she has any cause to believe, in the exercise of good faith, superior skill and careful judgment that continuation of the test is likely to result in injury, disability, or death to the participant, or is unlikely to produce the expected outcome through technical, Risk Management (RM), safety, or other analysis method. (paragraph 3)

Can anyone under 18 participate in a test?

No individual under the age of 18 will be a test participant. (paragraph 3)

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